What to do about tired eyes from too much reading and computer?

This is really a common problem nowadays. See your eye doctor and get a computer vision correction that will help you focus more accurately and with less effort. When prescribed properly, these glasses also can help you read printed material with greater ease, and the lenses can have tints and coatings to make your eyes feel a lot better!

I also recommend taking frequent breaks (every 15-30 minutes) where you look at something real far away, like out a window, to relax your focusing muscles. You should also make sure the lighting is correct for the activity you are doing — bright for reading and a bit dimmer for computer work, with no glare.